Loss of H3K9 trimethylation leads to premature aging
Author Information
Author(s): Ocampo Alejandro, Mrabti Calida, Yang Na, Desdín-Micó Gabriela, Alonso-Calleja Alejandro, Vílchez-Acosta Alba, Pico Sara, Parras Alberto, Piao Yulan, Schoenfeldt Lucas, Luo Siyuan, Haghani Amin, Brooke Robert T., Maza María del Carmen, Branchina Clémence, Maroun Céline Yacoub, von Meyenn Ferdinand, Naveiras Olaia, Horvath Steve, Sen Payel, Bignon Yohan
Hypothesis
The loss of H3K9me3 in adulthood results in premature aging.
Conclusion
The study shows that losing H3K9me3 leads to reduced lifespan and increased frailty in mice.
Supporting Evidence
- TKOc mice exhibit reduced lifespan and lower body weight.
- There is an increased frailty index and multi-organ degeneration in TKOc mice.
- The study shows significant upregulation of transposable elements in TKOc mice.
- Accelerated epigenetic age was observed in the mice with H3K9me3 loss.
Takeaway
When a specific chemical marker in cells is lost, it can make mice age faster and become weaker.
Methodology
The study used a novel mouse strain with a triple knockout of methyltransferases responsible for H3K9me3 deposition.
Digital Object Identifier (DOI)
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