Choline Levels and Breast Cancer Treatment Response
Author Information
Author(s): Jagannathan N R, Kumar M, Seenu V, Coshic O, Dwivedi S N, Julka P K, Srivastava A, Rath G K
Primary Institution: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
Hypothesis
The study investigates the relationship between total choline levels measured by MR spectroscopy and the response to neoadjuvant chemotherapy in locally advanced breast cancer.
Conclusion
The presence of choline before treatment and its reduction after treatment may indicate how well locally advanced breast cancer responds to chemotherapy.
Supporting Evidence
- The in-vivo MR spectra of malignant breast tissue showed a dominant water resonance.
- 80% of patients had a resonance at 3.2 ppm due to choline before treatment.
- 89% of patients showed absence or reduction of choline after neoadjuvant chemotherapy.
- The sensitivity of in-vivo MRS in detecting choline in malignant tumors was 78%.
- The specificity of in-vivo MRS in detecting choline in malignant tumors was 86%.
Takeaway
Doctors can use a special scan to see if a substance called choline is in breast cancer tissue, which helps them understand if the treatment is working.
Methodology
In-vivo proton magnetic resonance spectroscopy was used to analyze breast tissue samples from patients with breast cancer and benign lesions.
Participant Demographics
Patients included those with infiltrating ductal carcinoma and benign breast lesions, with a control group of volunteers.
Digital Object Identifier (DOI)
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