Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats
2000
IL-15 Helps Prevent Muscle Loss in Cancer
publication
Evidence: moderate
Author Information
Author(s): Carbó N, López-Soriano J, Costelli P, Busquets S, Alvarez B, Baccino F M, Quinn L S, López-Soriano F J, Argilés J M
Primary Institution: Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona
Hypothesis
Can IL-15 reduce muscle protein breakdown in cancer cachexia models?
Conclusion
IL-15 treatment significantly reduces muscle protein breakdown in tumor-bearing rats.
Supporting Evidence
- IL-15 treatment reduced protein degradation rates by 8-fold in tumor-bearing rats.
- The study showed that IL-15 did not change plasma levels of corticosterone and insulin.
- IL-15 inhibited the ATP-ubiquitin-dependent proteolytic pathway in muscle.
Takeaway
This study found that a substance called IL-15 can help stop muscles from wasting away in rats with cancer.
Methodology
The study used the Yoshida AH-130 rat model to measure protein degradation rates in muscle.
Participant Demographics
Tumor-bearing rats were used in the study.
Digital Object Identifier (DOI)
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