Long-lasting reduction of colorectal cancer risk after screening
Author Information
Author(s): Brenner H, Arndt V, Stürmer T, Stegmaier C, Ziegler H, Dhom G
Primary Institution: Department of Epidemiology, German Centre for Research on Ageing
Hypothesis
Does screening endoscopy lead to a long-term reduction in the risk of colorectal cancer?
Conclusion
Screening endoscopy significantly reduces the risk of colorectal cancer for more than 10 years, especially for advanced cases.
Supporting Evidence
- 11% of colorectal cancer cases had a history of endoscopy compared to 27% of controls.
- The adjusted odds ratio for risk reduction was 0.28.
- Risk reduction was also significant for those screened more than 10 years ago with an odds ratio of 0.41.
- Advanced colorectal cancer risk reduction was particularly strong with an odds ratio of 0.19.
Takeaway
Getting screened for colorectal cancer can help keep you safe for a long time, even many years after the screening.
Methodology
A statewide population-based case–control study comparing screening endoscopy history between colorectal cancer cases and controls.
Participant Demographics
320 cases with colorectal cancer aged 45–80 and 263 controls with other cancers.
Statistical Information
Confidence Interval
95% CI: 0.16–0.48
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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