Maternal and Neonatal Outcomes Related to Glycosylated Hemoglobin Levels in Pregnant Women with Diabetes
Author Information
Author(s): Kim Mi Ju, Park Suyeon, Choi Sooran, Hong Subeen, Sung Ji-Hee, Seol Hyun-Joo, Lee Joon Ho, Kim Seung Cheol, Choi Sae-Kyoung, Kwon Ji Young, Lee Seung Mi, Lee Se Jin, Hwang Han-Sung, Lee Gi Su, Park Hyun Soo, Lee Soo-Jeong, Cho Geum Joon, Bae Jin-Gon, Seong Won Joon, Ko Hyun Sun, Georgianos Panagiotis
Primary Institution: Kyungpook National University
Hypothesis
This study aimed to measure HbA1c levels in Korean women with pregestational diabetes during the first and second trimesters of pregnancy and evaluate the outcomes for mothers and newborns based on these levels.
Conclusion
The study found that second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes.
Supporting Evidence
- The study involved 292 mothers with pregestational diabetes.
- Statistically significant differences were found in neonatal birthweight and rates of large for gestational age (LGA) among the groups.
- HbA1c levels in the second trimester could predict pregnancy-associated hypertension (PAH) and LGA.
- Only 11.43% of mothers in the poorly-controlled group had good blood sugar control in the third trimester.
- 93% of mothers in the well-controlled group showed good glycemic control in the third trimester.
Takeaway
If pregnant women with diabetes keep their blood sugar levels in check during the second trimester, it can help them and their babies stay healthier.
Methodology
This was a retrospective cohort study involving 292 mothers with pregestational diabetes from 17 hospitals in South Korea, comparing HbA1c levels and maternal/neonatal outcomes.
Potential Biases
Selection bias may have occurred due to the study's focus on mothers at tertiary hospitals.
Limitations
The sample size was small, and there was potential selection bias as the study targeted mothers diagnosed and regularly followed up at tertiary hospitals.
Participant Demographics
The study involved Korean women with pregestational diabetes.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 1.390–6.075
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website