Dengue Virus Type 4 Detected in Manaus, Brazil
Author Information
Author(s): Pinto de Figueiredo Regina Maria, Naveca Felipe Gomes, de Souza Bastos Michele, do Nascimento Melo Miriam, de Souza Viana Suziane, Mourão Maria Paula Gomes, Costa Cristóvão Alves, Farias Izeni Pires
Primary Institution: Fundação de Medicina Tropical do Amazonas, Manaus, Brazil
Hypothesis
Is dengue virus type 4 present in Manaus, Brazil?
Conclusion
Dengue virus type 4 was detected in three patients in Manaus, indicating its presence in the region after 25 years.
Supporting Evidence
- DENV-4 was isolated from serum samples of three patients.
- All cases were confirmed by serologic and molecular tests.
- One patient was co-infected with DENV-3 and DENV-4.
Takeaway
Scientists found dengue virus type 4 in three people in Manaus, Brazil, which is important because it hasn't been seen there for a long time.
Methodology
Serum samples were collected and tested using virus culture, ELISA for IgM antibodies, and RT-PCR for nucleic acid amplification.
Limitations
The study only included three patients, which may not represent the broader population.
Participant Demographics
Patients lived and worked in Manaus and had no recent travel history.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website