EGFR Mutations in Breast and Lung Cancer
Author Information
Author(s): Weber F, Fukino K, Sawada T, Williams N, Sweet K, Brena R M, Plass C, Caldes T, Mutter G L, Villalona-Calero M A, Eng C
Primary Institution: The Ohio State University
Hypothesis
Differences in EGFR somatic mutational spectra and frequencies among different solid tumours may result in different responsiveness to treatment.
Conclusion
EGFR mutations occur at a significantly higher frequency in hereditary breast cancer compared to sporadic breast cancer, and many mutations are found in the tumour stroma.
Supporting Evidence
- EGFR mutations were found in 14.6% of sporadic breast cancer samples.
- 45.8% of hereditary breast cancer samples had EGFR mutations.
- 72.7% of mutations in hereditary breast cancers were located in the stroma.
Takeaway
This study looked at how different types of breast and lung cancers have different mutations in a gene called EGFR, which might affect how well treatments work.
Methodology
The study sequenced the TK domain of EGFR in 60 NSCLC samples, 48 sporadic breast carcinoma samples, and 24 hereditary breast cancer samples, analyzing both epithelial and stromal components.
Limitations
The study used anonymised archival material, limiting the ability to link results to treatment outcomes.
Participant Demographics
Included samples from non-small cell lung cancer, sporadic breast cancer, and hereditary breast cancer patients.
Statistical Information
P-Value
0.0079
Statistical Significance
p=0.0079
Digital Object Identifier (DOI)
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