The Genetic Causal Effect of Autoimmune Diseases on Pan-Cancers
Author Information
Author(s): Long Yubin, Pan Yujun, Yang Houzhi, Wang Xiangbin, Jiang Zichao, Sun Tianwei
Primary Institution: Tianjin Medical University
Hypothesis
This study aimed to investigate the causal effect of autoimmune diseases on pan-cancers through Mendelian randomization analysis.
Conclusion
This study provides novel genetic epidemiological evidence linking several autoimmune diseases to various cancers.
Supporting Evidence
- Inflammatory bowel disease significantly increases the risk of rectum cancer, basal cell carcinoma, and skin cancer.
- Rheumatoid arthritis significantly increases the risk of thyroid gland cancer while reducing the risk of overall cancers.
- Multiple sclerosis significantly increases the risk of overall cancers and reduces the risk of pancreas cancer.
Takeaway
Some diseases that make your immune system attack your own body can also increase the chances of getting cancer. This study looked at how these diseases might be connected to different types of cancer.
Methodology
The study used Mendelian randomization analysis with GWAS summary datasets of autoimmune diseases and cancers.
Potential Biases
Potential ethnic stratification bias due to the focus on the European population.
Limitations
The findings are limited to the European population and may not apply to other populations; cancers were classified by occurrence site rather than pathological type.
Participant Demographics
The study focused on the European population.
Statistical Information
P-Value
P<0.05
Confidence Interval
95% CI: 1.005, 1.126
Digital Object Identifier (DOI)
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