Somatostatin in Inflammatory Bowel Disease
1997
Somatostatin in Inflammatory Bowel Disease
publication
Evidence: low
Author Information
Author(s): J. D. van Bergeijk, J. H. P. Wilson
Primary Institution: University Hospital Dijkzigt, Rotterdam, The Netherlands
Hypothesis
The role of somatostatin as a neuroimmune modulator in inflammatory bowel disease (IBD) is explored.
Conclusion
Somatostatin may have beneficial effects in IBD and warrants further clinical studies.
Supporting Evidence
- Somatostatin is involved in the control of the intestinal immune system.
- Neuropeptides like somatostatin can have both pro- and anti-inflammatory effects.
- Active ulcerative colitis shows a higher serum level of somatostatin.
- Somatostatin analogues have been used to treat various gastrointestinal conditions.
Takeaway
Somatostatin is a substance in the body that helps control inflammation in the gut, and it might help people with certain gut diseases.
Methodology
The review discusses various studies on the role of somatostatin and neuropeptides in the immune response related to IBD.
Limitations
The review is based on indirect evidence and lacks systematic in vivo or in vitro studies specifically on somatostatin in IBD.
Want to read the original?
Access the complete publication on the publisher's website