Predicting Chemoradiation Therapy Response in Oesophageal Cancer
Author Information
Author(s): Okumura H, Natsugoe S, Matsumoto M, Mataki Y, Takatori H, Ishigami S, Takao S, Aikou T
Primary Institution: Kagoshima University
Hypothesis
Can the expression of p53, p53R2, and p21 predict the response to chemoradiation therapy in oesophageal squamous cell carcinoma?
Conclusion
The negative expression of p53 and p53R2 is associated with a favorable response to chemoradiation therapy in patients with oesophageal squamous cell carcinoma.
Supporting Evidence
- 71.0% of patients showed a clinical response to chemoradiation therapy.
- 52.8% of patients showed a histological response to chemoradiation therapy.
- 43.5% of patients had positive p53 expression.
- 37.1% of patients had positive p53R2 expression.
- 54.8% of patients had positive p21 expression.
Takeaway
Doctors can look at certain proteins in cancer cells to see if a treatment will work better for patients with oesophageal cancer.
Methodology
The study analyzed biopsy specimens from 62 patients with oesophageal squamous cell carcinoma to evaluate the expression of p53, p53R2, and p21 and their correlation with clinical and histological responses to chemoradiation therapy.
Potential Biases
Potential biases in patient selection and retrospective data collection.
Limitations
The study is retrospective and may not account for all variables affecting treatment response.
Participant Demographics
{"gender":{"male":61,"female":1},"age":{"mean":64,"range":"48-77"},"tumour_location":{"upper":15,"middle":34,"lower":13},"histological_type":{"well":10,"moderate":32,"poor":20}}
Statistical Information
P-Value
{"clinical_response":{"p53":{"negative":0.0001,"positive":null},"p53R2":{"negative":0.013,"positive":null}},"histological_response":{"p53":{"negative":0.041,"positive":null},"p53R2":{"negative":0.0018,"positive":null}}}
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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