Safety Evaluation of 18F-FLT for PET Imaging
Author Information
Author(s): Eric Turcotte, Linda W. Wiens, John R. Grierson, Lanell M. Peterson, Mark H. Wener, Hubert Vesselle
Primary Institution: University of Washington
Hypothesis
Is 18F-FLT safe for human PET imaging when administered in radiotracer doses?
Conclusion
This study shows no evidence of toxicity or complications attributable to 18F-FLT injected intravenously.
Supporting Evidence
- No side effects were reported during the study.
- Statistically significant decreases in albumin, red blood cell count, hematocrit, and hemoglobin were observed.
- The AUC12 values from imaging data were not significantly different from those found from blood samples.
Takeaway
The study tested a new imaging drug called 18F-FLT in 20 patients and found it to be safe with no side effects.
Methodology
Twenty patients received 18F-FLT injections, underwent PET imaging, and had blood samples taken for analysis.
Limitations
The study's findings may be influenced by surgical interventions that occurred shortly after the PET imaging.
Participant Demographics
12 men and 8 women, ages 45-81 years, with a mean age of 66.6 years for men and 60 years for women.
Statistical Information
P-Value
0.66
Statistical Significance
p = 0.66
Digital Object Identifier (DOI)
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