Study on Microalbuminuria in Type 1 Diabetes Patients
Author Information
Author(s): Cobas Roberta A, Santos Bráulio, da Silva Pedro CB, Neves Ricardo, Gomes Marilia B
Primary Institution: State University of Rio de Janeiro
Hypothesis
The study aimed to determine the incidence and evaluate the baseline predictors for the development of microalbuminuria in patients with type 1 diabetes.
Conclusion
Higher BMI and cholesterol/HDL ratio increased the risk of developing microalbuminuria in young patients with type 1 diabetes.
Supporting Evidence
- 41% of patients developed microalbuminuria over 6.81 years of follow-up.
- The incidence density was 6.79/100 people per year.
- Independent factors for microalbuminuria included BMI and cholesterol/HDL ratio.
Takeaway
This study found that being overweight and having high cholesterol can make young people with type 1 diabetes more likely to have kidney problems.
Methodology
A longitudinal cohort study of 122 normoalbuminuric patients with type 1 diabetes was conducted, with regular examinations and analysis of predictors using Cox regression.
Potential Biases
Potential bias due to the exclusion of patients with existing nephropathy and reliance on self-reported family history.
Limitations
Variable follow-up time and difficulty in characterizing ethnicity in the study population.
Participant Demographics
Patients were young adults with type 1 diabetes, primarily normoalbuminuric at baseline.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI 1.03-1.21 for BMI; 95% CI 1.05-1.67 for cholesterol/HDL ratio
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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