Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2/CYP2E1 Cells
2011
Protective Effects of Emodin and Chrysophanol from Marine Fungus on Liver Cell Toxicity
publication
Evidence: moderate
Author Information
Author(s): Qian Zhong-Ji, Zhang Chen, Li Yong-Xin, Je Jae-Young, Kim Se-Kwon, Jung Won-Kyo
Primary Institution: Chosun University
Hypothesis
Can emodin and chrysophanol isolated from marine fungus Aspergillus sp. protect against ethanol-induced toxicity in liver cells?
Conclusion
Emodin and chrysophanol can reduce ethanol-induced cell damage in liver cells by inhibiting certain toxic effects and increasing antioxidant levels.
Supporting Evidence
- Emodin and chrysophanol were shown to increase cell viability in the presence of ethanol.
- Both compounds reduced the activity of gamma-glutamyltransferase (GGT) in treated cells.
- Emodin was more effective than chrysophanol in protecting against ethanol-induced cytotoxicity.
Takeaway
This study found that two natural compounds from a marine fungus can help protect liver cells from damage caused by alcohol.
Methodology
The study involved treating HepG2/CYP2E1 cells with emodin and chrysophanol before exposing them to ethanol and measuring cell viability and enzyme activity.
Digital Object Identifier (DOI)
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