Admixture of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Peripheral Nerve Blocks in Adolescents Undergoing Orthopedic Surgery: An Observational Cohort Study
2024

Liposomal Bupivacaine for Pain Relief in Teenagers After Surgery

Sample size: 374 publication Evidence: moderate

Author Information

Author(s): Fiorillo Benjamin P., Melton M. Stephen, Nelsen Derek, Einhorn Lisa M.

Primary Institution: Duke University Medical Center

Hypothesis

Can liposomal bupivacaine/bupivacaine hydrochloride provide effective pain relief in adolescents undergoing orthopedic surgery?

Conclusion

Liposomal bupivacaine/bupivacaine hydrochloride PNBs were successfully used in adolescents for orthopedic surgeries, resulting in high patient satisfaction and effective pain management.

Supporting Evidence

  • 524 peripheral nerve blocks were performed in 374 patients.
  • 77% of patients reported no pain in the post-anesthesia care unit.
  • 96% of surveyed patients were satisfied with their pain control after surgery.

Takeaway

Doctors used a special medicine to help kids feel less pain after surgery, and most kids said it worked really well.

Methodology

The study reviewed patient records and conducted follow-up surveys to assess outcomes after administering liposomal bupivacaine/bupivacaine hydrochloride PNBs.

Potential Biases

Potential bias due to the retrospective nature of the study and the lack of a control group.

Limitations

The study was not comparative and had a limited follow-up period for patient-reported outcomes.

Participant Demographics

Participants were adolescents aged 11 to 17 years, with a mean age of 16 years, including both males and females.

Digital Object Identifier (DOI)

10.3390/jcm13247586

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