Using Breath Analysis to Diagnose Ischemic Heart Disease
Author Information
Author(s): Marzoog Basheer Abdullah, Chomakhidze Peter, Gognieva Daria, Gagarina Nina Vladimirovna, Silantyev Artemiy, Suvorov Alexander, Fominykha Ekaterina, Mustafina Malika, Natalya Ershova, Gadzhiakhmedova Aida, Kopylov Philipp
Primary Institution: World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University
Hypothesis
Patients with ischemic heart disease have different levels of volatile organic compounds (VOCs) in their exhaled air.
Conclusion
The analysis of volatile organic compounds in exhaled breath can effectively distinguish between individuals with and without ischemic heart disease.
Supporting Evidence
- The VOCs specificity was 77.6% and sensitivity was 83.9%.
- The area under the curve (AUC) for VOCs was 83.8%.
- The study included 80 participants, with 31 having ischemic heart disease.
- Statistical processing was performed using R and Python programming languages.
- The study was registered on clinicaltrials.gov (NCT06181799).
Takeaway
Doctors can tell if someone has heart disease by looking at what they breathe out, which is like checking for special smells.
Methodology
A single-center observational study using mass spectrometry to analyze exhaled breath from participants during physical exertion tests.
Potential Biases
Potential biases may arise from the non-randomized design and the single-center nature of the study.
Limitations
The study lacks external validation due to the unique equipment used, which is not widely available.
Participant Demographics
Participants were aged 40 years and older, including both males and females.
Statistical Information
P-Value
0.003
Confidence Interval
[95% CI; 0.73655857; 0.91493173]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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