Comparing Methods for Genetic Linkage Detection on Chromosome 17
Author Information
Author(s): Mariza de Andrade, Curtis Olswold
Primary Institution: Mayo Clinic
Hypothesis
Can different statistical methods effectively detect genetic linkage for systolic blood pressure using longitudinal data?
Conclusion
The study found no evidence of genetic linkage for systolic blood pressure on chromosome 17, except under specific conditions.
Supporting Evidence
- No evidence of linkage was found using either method except under specific conditions.
- The maximum LOD score using the longitudinal approach was 0.96.
- Linkage evidence was only observed when analyzing all time points and restricting subjects' ages.
Takeaway
The researchers looked at two ways to find genes that affect blood pressure but didn't find strong evidence for any genes on chromosome 17.
Methodology
The study compared a variance components approach and a regression-based approach using data from the Framingham Heart Study.
Potential Biases
Potential bias due to missing values and differences in treatment adjustments between methods.
Limitations
The analysis was affected by missing data, which was handled differently in the two methods.
Participant Demographics
Subjects were from the Framingham Heart Study, with a focus on ages 25 to 75 for some analyses.
Digital Object Identifier (DOI)
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