Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk
1999
Genetic Variation in Aromatase Gene and Breast Cancer Risk
Sample size: 493
publication
Evidence: moderate
Author Information
Author(s): Siegelmann-Danieli N, Buetow K H
Primary Institution: Fox Chase Cancer Center
Hypothesis
Constitutional genetic variation in the human aromatase gene (Cyp19) contributes to breast cancer risk.
Conclusion
Genetic variation at the Cyp19 locus is linked to an increased risk of developing breast cancer, particularly associated with the 171-bp allele.
Supporting Evidence
- The study involved 348 breast cancer cases and 145 controls.
- A significant difference in allelic distribution was found between cases and controls.
- The 171-bp allele was over-represented in breast cancer cases.
Takeaway
Some people have a gene that makes them more likely to get breast cancer, and we found that a specific part of this gene is linked to that risk.
Methodology
Genotyping of 348 breast cancer cases and 145 controls for a tetranucleotide repeat polymorphism at intron 4 of the Cyp19 gene.
Participant Demographics
All participants were Caucasian women.
Statistical Information
P-Value
0.019
Statistical Significance
p=0.019
Digital Object Identifier (DOI)
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