ACE I/D Gene Polymorphism and Steroid Responsiveness in Asian Children with Nephrotic Syndrome
Author Information
Author(s): Zhou Tian-Biao, Qin Yuan-Han, Su Li-Na, Lei Feng-Ying, Huang Wei-Fang, Zhao Yan-Jun
Primary Institution: The First Affiliated Hospital of GuangXi Medical University, NanNing, China
Hypothesis
Can ACE I/D gene polymorphism predict steroid responsiveness in Asian children with idiopathic nephrotic syndrome?
Conclusion
The study found that ACE D allele or DD genotype cannot predict the treatment response to steroids in Asian children with idiopathic nephrotic syndrome.
Supporting Evidence
- Five studies were included in the analysis of SRNS susceptibility.
- Seven studies were included to explore SSNS susceptibility.
- II genotype might play a positive role against SRNS onset but not for SSNS.
Takeaway
This study looked at whether a specific gene could help doctors know if kids with a kidney problem would respond to steroid medicine, and it found that it can't.
Methodology
The study performed a meta-analysis of existing research on ACE I/D gene polymorphism and steroid responsiveness in Asian children with nephrotic syndrome.
Potential Biases
Potential biases due to the exclusion of studies conducted in non-Asian populations.
Limitations
The study was limited by the heterogeneity of included studies and the small number of investigations.
Participant Demographics
The study focused on Asian children with idiopathic nephrotic syndrome.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI: 1.04–1.83
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website