What Are Fungal Infections?
2011
Understanding Fungal Infections
Editorial
Evidence: moderate
Author Information
Author(s): Ben E. de Pauw
Primary Institution: University Medical Center St Radboud
Hypothesis
Why have fungi evolved to become significant threats to seriously ill patients?
Conclusion
Fungal infections are increasingly common in immunocompromised patients due to modern treatment modalities that weaken the immune system.
Supporting Evidence
- Fungi are now among the top 10 pathogens in febrile patients with weakened immune systems.
- Approximately 7% of febrile episodes during neutropenia are due to invasive fungal infections.
- Candida has become the fourth leading bloodstream isolate in hospitals in the USA.
Takeaway
Fungi can make people very sick, especially if their body's defenses are weak. This happens a lot in hospitals where patients are getting strong treatments.
Limitations
The incidence of fungal infections may be underestimated due to low autopsy rates and non-specific symptoms.
Participant Demographics
Patients with impaired immune systems, particularly those undergoing aggressive treatments for hematological malignancies.
Digital Object Identifier (DOI)
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