Avascular Necrosis in Testicular Cancer Patients Treated with Chemotherapy
Author Information
Author(s): Cook A M, Dzik-Jurasz A S K, Padhani A R, Norman A, Huddart R A
Primary Institution: The Royal Marsden NHS Trust and Institute of Cancer Research
Hypothesis
What is the prevalence of avascular necrosis in patients treated with chemotherapy for testicular tumors?
Conclusion
Avascular necrosis is an uncommon but significant complication of chemotherapy for testicular cancer.
Supporting Evidence
- Four out of 47 patients scanned had evidence of avascular necrosis.
- Four out of 103 patients invited to participate had evidence of avascular necrosis.
- The 3-year actuarial risk of avascular necrosis was found to be 6.3%.
Takeaway
This study looked at how many people getting treatment for testicular cancer had a problem called avascular necrosis, and found that it's not very common but can happen.
Methodology
MRI scans were performed on 103 consecutive patients treated with chemotherapy.
Limitations
Not all patients had completed the at-risk period.
Participant Demographics
Patients treated with chemotherapy for testicular cancer.
Statistical Information
Confidence Interval
95% confidence limits (CI) 2.4–16.1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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