S100 Gene Expression in Gastric Cancer
Author Information
Author(s): Liu Ji, Li Xue, Dong Guang-Long, Zhang Hong-Wei, Chen Dong-Li, Du Jian-Jun, Zheng Jian-Yong, Li Ji-Peng, Wang Wei-Zhong
Primary Institution: Xijing Hospital, The Fourth Military Medical University
Hypothesis
The expression status of S100 family members in gastric cancer is not known yet.
Conclusion
The study found that S100A3 is overexpressed in gastric cancer and may play important roles in tumor differentiation and progression.
Supporting Evidence
- At least 5 S100 genes were found to be upregulated in gastric cancer.
- S100A3 expression was correlated with tumor differentiation and TNM stage.
- The mean expression levels of S100A3 in gastric cancer tissues were 2.5 times higher than in adjacent non-tumorous tissues.
Takeaway
This study looked at certain genes in stomach cancer and found that one gene, S100A3, is much more active in cancer than in normal tissue.
Methodology
The study used SAGE, virtual Northern blot, and microarray analysis to investigate S100 gene expression in gastric cancer tissues.
Participant Demographics
80 patients with gastric cancer who underwent surgery.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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