S100A8/A9 Complex in Systemic Lupus Erythematosus
Author Information
Author(s): Christian Lood, Martin Stenström, Helena Tydén, Birgitta Gullstrand, Eva Källberg, Tomas Leanderson, Lennart Truedsson, Gunnar Sturfelt, Fredrik Ivars, Anders Bengtsson
Primary Institution: Lund University
Hypothesis
Can aberrant cell surface S100A8/A9 be observed in systemic lupus erythematosus (SLE) and can plasmacytoid dendritic cells synthesize S100A8/A9?
Conclusion
Patients with SLE had increased cell surface S100A8/A9, which may play a role in inflammation persistence.
Supporting Evidence
- SLE patients had increased serum levels of S100A8/A9.
- Cell surface S100A8/A9 was higher in patients with active disease compared to those with inactive disease.
- Plasmacytoid dendritic cells were able to synthesize S100A8/A9.
Takeaway
This study found that a protein complex called S100A8/A9 is more present on certain immune cells in people with lupus, which might help explain why they have ongoing inflammation.
Methodology
Flow cytometry, confocal microscopy, and real-time PCR were used to measure S100A8/A9 levels in leukocyte subpopulations.
Potential Biases
Potential bias due to the recruitment of patients from a single center.
Limitations
The study did not explore the exact biological functions of S100A8/A9 in SLE.
Participant Demographics
{"age":{"median":42,"range":"19 to 81"},"gender":{"female_percentage":94,"male_percentage":6}}
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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