Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts)
2001
Distinguishing Malignant Melanoma from Clear Cell Sarcoma
Sample size: 33
publication
Evidence: moderate
Author Information
Author(s): Langezaal S M, Graadt van Roggen J F, Cleton-Jansen A M, Baelde J J, Hogendoorn P C W
Primary Institution: Leiden University Medical Center
Hypothesis
The study investigates whether the chromosomal translocation t(12;22)(q13;q13) is present in malignant melanoma.
Conclusion
The translocation t(12;22)(q13;q13) was not found in any of the melanomas or melanoma cell lines, but was identified in some clear cell sarcomas, aiding in their differentiation.
Supporting Evidence
- The translocation t(12;22)(q13;q13) was identified in 3 out of 5 clear cell sarcomas.
- No melanomas or melanoma cell lines showed the translocation.
- The study provides a molecular genetic tool for differentiating between clear cell sarcoma and malignant melanoma.
Takeaway
Doctors can tell the difference between two types of skin tumors by looking for a specific change in their genes.
Methodology
The study used RT-PCR and FISH to screen for the t(12;22)(q13;q13) translocation in melanoma samples and cell lines.
Digital Object Identifier (DOI)
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