GPR125 Expression in the Choroid Plexus After Brain Injury
Author Information
Author(s): Chris Pickering, Maria Hägglund, Joanna Szmydynger-Chodobska, Fernanda Marques, Joana A Palha, Linn Waller, Adam Chodobski, Robert Fredriksson, Malin C Lagerström, Helgi B Schiöth
Primary Institution: Uppsala University
Hypothesis
GPR125 expression changes in response to brain injury.
Conclusion
GPR125 expression increases in the choroid plexus shortly after traumatic brain injury and is delayed in the hippocampus.
Supporting Evidence
- GPR125 expression was transiently increased almost 2-fold at 4 hours after traumatic brain injury.
- GPR125 expression in the hippocampus was delayed until 1 day after injury.
- Induction of inflammation by LPS did not change GPR125 expression.
Takeaway
GPR125 is a protein that helps the brain respond to injuries, and its levels go up after a brain injury happens.
Methodology
The study used in situ hybridization, immunohistochemistry, and qPCR to analyze GPR125 expression in mouse brain and peripheral tissues.
Participant Demographics
Adult male Sv129 mice were used for the experiments.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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