Impact of Tumor Stage and Histopathology on Survival in Esophageal Cancer
Author Information
Author(s): Bangolo Ayrton, Nagesh Vignesh Krishnan, Simonson Grace, Thapa Abhishek, Ram Arun, Santhakumari Nithin Jayan, Chamroukh Rayan, Varughese Vivek Joseph, Nareeba Shallot, Menon Aiswarya, Sridharan Kousik, Chacko Angel Ann, Mansour Charlene, Elias Daniel, Singh Gurinder R., Rambaransingh Aaron, Mendez Luis Roman, Levy Charlotte, Kianifar Aguilar Izage, Hamad Ibrahim, Sharma Urveesh, Salcedo Jose, Tran Hadrian Hoang-Vu, Haq Abdullah, Geleto Tahir B., Jean Kaysha, Periel Luis, Bravin Sara, Weissman Simcha
Primary Institution: Hackensack University Medical Center
Hypothesis
The study aims to assess the impact of staging and histopathology of esophageal cancer on associated mortality.
Conclusion
The study identifies significant demographic and clinicopathologic factors influencing mortality in esophageal cancer patients, emphasizing the importance of early diagnosis and treatment intervention.
Supporting Evidence
- 80.13% of patients were male, indicating a higher prevalence in men.
- 59.86% of patients were aged 60-79, highlighting the age group most affected.
- 68.17% of tumors were adenocarcinoma, showing its predominance.
- 41.29% of patients were diagnosed at a distant stage, indicating late diagnosis.
- Patients receiving surgery had significantly lower mortality rates.
Takeaway
This study looks at how different types of esophageal cancer and their stages affect how long patients live. It shows that early treatment can help people live longer.
Methodology
A retrospective cohort study using data from the SEER database, analyzing demographic parameters, tumor stage, and histologic subtypes in relation to overall and cancer-specific mortality.
Potential Biases
Potential biases related to patient selection and completeness of medical records due to the retrospective nature of the study.
Limitations
The study relies on the SEER database, which may not capture all patients or reflect regional variations in treatment and outcomes; it is also retrospective and lacks detailed treatment information.
Participant Demographics
The cohort predominantly consisted of males (80.13%), aged 60-79 (59.86%), mostly non-Hispanic white (77.87%), and a significant portion were married (55.44%).
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI 1.02–1.10
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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