Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation
1993
Effects of Diet and Surgery on Pancreatic Cancer
publication
Evidence: moderate
Author Information
Author(s): P. Watanapa, R.C.N. Williamson
Primary Institution: Royal Postgraduate Medical School, Hammersmith Hospital
Hypothesis
Hyperplasia and neoplasia are linked in the exocrine pancreas.
Conclusion
Dietary factors and surgical manipulations can significantly influence pancreatic growth and the development of cancer.
Supporting Evidence
- Diets high in trypsin inhibitors stimulate pancreatic growth and increase cancer risk in rats.
- Fatty acids enhance pancreatic carcinogenesis in both rats and hamsters.
- Surgical operations like pancreatobiliary diversion stimulate pancreatic growth and carcinogenesis.
Takeaway
Eating certain foods and having specific surgeries can make the pancreas grow more and increase the chances of getting cancer.
Methodology
The review examines various studies on dietary and surgical effects on pancreatic growth and cancer in rodent models.
Limitations
Few data exist in humans, primarily focusing on rodent models.
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