Effect of a tumour-produced lipid-mobilizing factor on protein synthesis and degradation
2001
Effect of Tumor-Produced Lipid on Protein Synthesis
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Islam-Ali B S, Tisdale M J
Primary Institution: Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
Hypothesis
Does a tumor-produced lipid-mobilizing factor affect protein synthesis and degradation?
Conclusion
The tumor-produced lipid-mobilizing factor increases protein accumulation in skeletal muscle by enhancing protein synthesis and reducing protein degradation.
Supporting Evidence
- The lipid-mobilizing factor caused a concentration-dependent stimulation of protein synthesis.
- There was a 69% increase in protein synthesis in soleus muscles of mice administered LMF.
- Protein degradation decreased by 26% in the presence of LMF.
Takeaway
A substance made by tumors can help muscles make more protein and break down less protein.
Methodology
Murine myoblasts, myotubes, and tumor cells were treated with a lipid-mobilizing factor to assess its effects on protein synthesis and degradation.
Participant Demographics
Mice were used in the study.
Statistical Information
P-Value
P = 0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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