Outbreak of Severe Infections with Community-Acquired MRSA Following Vaccination
Author Information
Author(s): Chi Thuong Tang, Dac Tho Nguyen, Thi Hoa Ngo, Minh Phuong Nguyen Thi, Van Tuan Le, Song Diep To, Lindsay Jodi, The Dung Nguyen, Van Cam Bach, Quoc Thinh Le, Thanh Hai Le, Dieu Linh Le, Campbell James, Kim Tien Nguyen Thi, Vinh Chau Nguyen Van, Cockfield Joshua, Truong Giang Le, Van Nghiem Phan, Hoang Son Le, Tan Son Huynh, Van Phung Le, Counahan Megan, Bentsi-Enchill Adwoa, Brown Richard, Simmerman James, Tran Chinh Nguyen, Tinh Hien Tran, Farrar Jeremy, Schultsz Constance
Primary Institution: Pediatric Hospital No. 1, Ho Chi Minh City, Viet Nam
Hypothesis
What caused the outbreak of severe CA-MRSA infections in children after vaccination?
Conclusion
The outbreak of CA-MRSA infections in children was linked to transmission by an asymptomatic health care worker during immunization.
Supporting Evidence
- Nine children presented with severe infections after vaccination in Ho Chi Minh City.
- Four children were found to be infected with CA-MRSA, which was also cultured from the health care worker.
- The infections included toxic shock syndrome and necrotizing soft tissue infections.
Takeaway
Some kids got really sick after getting their vaccines because a nurse who didn't know she was carrying a germ passed it to them.
Methodology
The study involved a field investigation, clinical data review, and microbiological analysis of samples from affected children and health care workers.
Potential Biases
Potential bias due to reliance on self-reported data from health care workers and parents.
Limitations
The study did not investigate MRSA carriage in the affected children, and additional diagnostic specimens were not obtained.
Participant Demographics
All children were previously healthy and aged between 5 to 17 months.
Digital Object Identifier (DOI)
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