Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq
2024
Effects of Macrocyclic Lactones on Toxocara canis Larvae
publication
Author Information
Author(s): Quintana Theresa A., Brewer Matthew T., Chelladurai Jeba R. Jesudoss
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
How do macrocyclic lactones affect the transcriptional responses in Toxocara canis larvae?
Conclusion
Macrocyclic lactones significantly alter the transcriptional regulation in Toxocara canis larvae.
Supporting Evidence
- Ivermectin treatment resulted in 608 differentially expressed genes.
- Moxidectin treatment resulted in 1,413 differentially expressed genes.
- Many differentially expressed genes were involved in critical biological processes.
Takeaway
This study shows that certain treatments can change how Toxocara canis larvae behave at a genetic level.
Methodology
The study used RNA sequencing to analyze transcriptional changes in Toxocara canis larvae treated with ivermectin and moxidectin.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website