Vascular Density and Phenotype in Ductal Carcinoma In Situ of the Breast
Author Information
Author(s): Teo N B, Shoker B S, Jarvis C, Martin L, Sloane J P, Holcombe C
Primary Institution: University of Liverpool
Hypothesis
The development of invasive carcinoma in DCIS is associated with changes in periductal vessels.
Conclusion
The greater density of CD34+ and CD141+ vessels around DCIS associated with invasive carcinoma could reflect a greater predisposition to invade.
Supporting Evidence
- DCIS associated with invasive carcinoma showed significantly greater numbers of CD34+ and CD141+ vessels.
- There was a significant negative correlation between vascular density and the extent of necrosis of the tumour.
- MVD increased from low to intermediate nuclear grade but decreased in high grade DCIS.
Takeaway
This study looked at how blood vessels around a type of breast cancer called DCIS might change when it becomes more serious. More blood vessels could mean the cancer is more likely to spread.
Methodology
The study used morphometry and immunohistochemistry to assess vascular density and phenotype in breast samples.
Potential Biases
Potential bias in assessing vascular density due to proximity to invasive carcinoma.
Limitations
The study may not fully exclude the effects of co-existent invasive carcinoma on vascular changes.
Participant Demographics
Patients with ductal carcinoma in situ, with and without invasive carcinoma.
Statistical Information
P-Value
p=0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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