Impact of Donor Smoking on Kidney Function After Transplant
Author Information
Author(s): Jonathan Heldt, Robert Torrey, Daniel Han, Pedro Baron, Christopher Tenggardjaja, Justin McLarty, Tekisha Lindler, D. Duane Baldwin
Primary Institution: Loma Linda University Medical Center
Hypothesis
Does smoking by kidney donors negatively affect the renal function of both donors and recipients?
Conclusion
Tobacco use by kidney donors is associated with decreased posttransplant renal function, although smoking cessation can improve outcomes.
Supporting Evidence
- Recipients of kidneys from smoking donors had a smaller percent decline in postoperative creatinine compared to those from non-smoking donors.
- Smoking cessation by donors can lead to improved kidney function outcomes.
- Donors who smoke showed a greater percent increase in creatinine levels post-donation.
Takeaway
If a person who donates a kidney smokes, it can hurt both their kidney function and the function of the kidney they give away. Quitting smoking can help.
Methodology
A retrospective review of 100 kidney donors and their recipients, comparing smoking and non-smoking donors.
Potential Biases
The retrospective nature of the study may introduce biases in data collection and analysis.
Limitations
The study is retrospective with small sample sizes and limited follow-up time.
Participant Demographics
29 smoking donors and 71 non-smoking donors, with no significant differences in age, BMI, or comorbidities.
Statistical Information
P-Value
0.015
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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