Bcl10 is not a target for frequent mutation in human carcinomas
1999
Bcl10 is not a target for frequent mutation in human carcinomas
Sample size: 174
publication
Evidence: high
Author Information
Author(s): Lambers A R, Gumbs C, Ali S, Marks J R, Iglehart J D, Berchuck A, Futreal P A
Primary Institution: Duke University Medical Center
Hypothesis
Is the Bcl10 gene a major target for inactivation in human cancers?
Conclusion
Bcl10 is not commonly mutated in various adult malignancies.
Supporting Evidence
- No deleterious mutations were detected in any of the samples analysed.
- The study screened a panel of 174 carcinoma samples.
- The panel included various types of carcinomas.
Takeaway
The study looked at a lot of cancer samples and found that a gene called Bcl10 is not usually broken in these cancers.
Methodology
The study analyzed 174 carcinoma samples for mutations in the Bcl10 gene.
Participant Demographics
The samples included 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal, and 20 head/neck carcinomas.
Digital Object Identifier (DOI)
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