Examining the moderating effects of biopsychosocial factors on the relationship between HIV-related depression and cognitive function among adolescents living with HIV in Tanzania: A protocol for an analytical cross-sectional study
2025

Effects of biopsychosocial factors on HIV-related depression and cognitive function in adolescents with HIV

Sample size: 207 publication Evidence: moderate

Author Information

Author(s): Kitoki Siku, Seif Saada Ali, Masika Golden Mwakibo

Primary Institution: University of Dodoma, Dodoma, Tanzania

Hypothesis

This study aims to examine the moderating effects of biopsychosocial factors on the bi-directional relationship between HIV-related depression and cognitive function among adolescents living with HIV in Tanzania.

Conclusion

The study will provide insights that could help develop integrated care models addressing both mental and cognitive health for adolescents living with HIV.

Supporting Evidence

  • Adolescents living with HIV face unique challenges, including mental health issues such as depression and cognitive dysfunction.
  • Depression is a serious mental health condition that significantly affects daily functioning.
  • Evidence shows that cognitive impairment is a prominent component of major depressive disorder.

Takeaway

This study is looking at how different factors affect depression and thinking skills in teenagers with HIV in Tanzania.

Methodology

An analytical cross-sectional study involving 207 adolescents living with HIV, using standardized tools to assess depression and cognitive function.

Potential Biases

Potential biases may arise from self-reported data and the specific healthcare settings chosen for participant recruitment.

Limitations

The study may not account for all potential confounding factors affecting depression and cognitive function.

Participant Demographics

Adolescents aged 15-19 years living with HIV in the Mbeya region of Tanzania.

Statistical Information

P-Value

0.05

Confidence Interval

95%

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0313223

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