Gene Expressions in Embryo Culture Medium
Author Information
Author(s): Kılıç Nergis Özlem, Kütük Duygu, Öner Çağrı, Öztürk Senem Aslan, Selam Belgin, Çolak Ertuğrul
Primary Institution: Maltepe University
Hypothesis
Low hTERT gene expression and high HIF-1α gene expression profiles cause non-developing embryos.
Conclusion
Higher hTERT and lower HIF-1α gene expressions are associated with developing embryos.
Supporting Evidence
- An increase in hTERT gene expression was observed in developing embryos.
- A decrease in HIF-1α gene expression was noted in developing embryos.
- No difference was found in Ki-67 gene expression between developing and non-developing embryos.
Takeaway
This study looked at how certain genes in the fluid where embryos grow can tell us if they will develop properly or not.
Methodology
The study analyzed gene expressions from spent embryo culture medium of developing and non-developing embryos from normoresponder patients.
Limitations
The study focused only on normoresponder patients and did not explore other patient demographics.
Participant Demographics
Women aged 22 to 43 from the Bahçeci Health Group Umut IVF Center.
Statistical Information
P-Value
p < 0.05 for hTERT and p < 0.001 for HIF-1α.
Digital Object Identifier (DOI)
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