Moxifloxacin for Treating Acute Bacterial Sinusitis
Author Information
Author(s): Horacio Ariza, Ramon Rojas, Peter Johnson, Richard Gower, Alice Benson, Janet Herrington, Renee Perroncel, Peter Pertel
Hypothesis
What is the time to bacteriologic eradication in patients with acute bacterial sinusitis treated with moxifloxacin?
Conclusion
Moxifloxacin 400 mg once daily for 10 days resulted in eradication of baseline bacteria in 83.3% of patients by Day 2, 100% by Day 3, and 97.6% by Day 4.
Supporting Evidence
- Moxifloxacin was effective in eradicating bacteria in 83.3% of patients by Day 2.
- All patients in the per-protocol evaluation were bacteriologically evaluable at Days 2, 3, and 4.
- Clinical success was achieved in 94.7% of patients at the test of cure visit.
Takeaway
This study shows that a medicine called moxifloxacin can help get rid of germs in the nose very quickly for people with a sinus infection.
Methodology
Adult patients with confirmed acute bacterial sinusitis received moxifloxacin 400 mg once daily for 10 days, with nasal endoscopy performed for sampling.
Potential Biases
Potential bias due to the open-label design and lack of a control group.
Limitations
The study was not designed to test whether a shortened moxifloxacin course is effective in the treatment of ABS.
Participant Demographics
{"sex_distribution":{"male":31.0,"female":69.0},"mean_age":41.0,"race_distribution":{"white":81.0,"hispanic":14.3,"black":4.8}}
Statistical Information
P-Value
0.0001
Confidence Interval
{"day_2":"68.6, 93.0","day_3":"91.6, 100","day_4":"87.4, 99.9"}
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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