Osteopontin's Role in Vascular Adventitial Fibroblasts and Vascular Remodeling
Author Information
Author(s): Jin Xin, Fu Guo-xiang, Li Xiao-dong, Zhu Ding-liang, Gao Ping-jin
Primary Institution: State Key Laboratory of Medical Genomics and Shanghai Key Laboratory of Vascular Biology, Shanghai JiaoTong University School of Medicine, Ruijin Hospital, Shanghai, China
Hypothesis
OPN is upregulated in vascular advential by renin-angiotensin-aldosterone system, which thus plays an important role in neointima formation.
Conclusion
The study concluded that upregulation of Osteopontin expression in adventitial fibroblasts might be important in the pathogenesis of vascular remodeling after arterial injury.
Supporting Evidence
- Angiotensin II and aldosterone increased Osteopontin expression in adventitial fibroblasts in a time- and concentration-dependent manner.
- MAPKs and AP-1 pathways were involved in Osteopontin upregulation.
- Adventitial fibroblast migration stimulated by Angiotensin II and aldosterone required OPN expression.
- Perivascular delivery of antisense oligonucleotide for Osteopontin suppressed neointimal formation post-injury.
Takeaway
Osteopontin helps cells in blood vessels move and grow when they are injured, which can lead to problems in the blood vessels.
Methodology
The study measured Osteopontin activation and its biological functions in cultured adventitial fibroblasts and injured rat carotid arteries induced by balloon angioplasty.
Participant Demographics
Male Sprague-Dawley rats aged 12-14 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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