Nucleosome DNA sequence structure of isochores
2011
Nucleosome DNA Sequence Structure of Isochores
publication
Evidence: moderate
Author Information
Author(s): Frenkel Zakharia M, Bettecken Thomas, Trifonov Edward N
Hypothesis
The nucleosome positioning patterns in DNA of the isochores should be different due to significant differences in G+C content.
Conclusion
Nucleosome positioning patterns are strongly dependent on G+C content and vary between different isochore types.
Supporting Evidence
- The dominant positioning patterns of isochores vary due to large differences in G+C composition.
- Human sequences show CG periodicity, while chicken isochores display AG periodicity.
Takeaway
Different parts of DNA, called isochores, have different patterns for how DNA is wrapped around proteins, and this is influenced by the amount of G and C in the DNA.
Methodology
The study used Shannon N-gram extension analysis to extract patterns from isochore DNA sequences.
Limitations
The study may not account for all factors influencing nucleosome positioning due to the complexity of genomic sequences.
Digital Object Identifier (DOI)
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