Vitamin D Levels and Survival in Advanced Biliary Tract Cancer
Author Information
Author(s): So Heun Lee, Jaekyung Cheon, Ilhwan Kim, Kyu‐pyo Kim, Baek‐Yeol Ryoo, Jae Ho Jeong, Myoung Joo Kang, Byung Woog Kang, Hyewon Ryu, Ji Sung Lee, Changhoon Yoo
Primary Institution: Asan Medical Center, University of Ulsan College of Medicine
Hypothesis
What is the relationship between serum vitamin D levels and overall survival in patients with advanced biliary tract cancer undergoing second-line chemotherapy?
Conclusion
Higher serum vitamin D levels were associated with worse overall survival in female patients with advanced biliary tract cancer, but not in the overall population.
Supporting Evidence
- Serum 25(OH)D levels were not associated with overall survival in the overall patient population.
- Higher serum 25(OH)D levels were linked to worse overall survival in female patients.
- Subgroup analyses indicated significant interaction effects by sex and body mass index.
Takeaway
This study looked at how vitamin D levels affect survival in patients with a type of cancer. It found that for women, higher vitamin D levels might mean they don't live as long.
Methodology
This was a preplanned subgroup analysis of the NIFTY trial, comparing serum vitamin D levels and overall survival in patients receiving different chemotherapy regimens.
Potential Biases
Limited generalizability due to the study population being primarily Asian and the lack of consideration for molecular alterations.
Limitations
The study only measured vitamin D levels at one point in time and did not account for seasonal variability.
Participant Demographics
Median age was 64 years, with 42.8% women; 40.5% normal weight, 5.8% underweight, 23.1% overweight, and 28.9% obese.
Statistical Information
P-Value
0.009 for female patients
Confidence Interval
95% CI, 1.04–1.28
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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