Increased p38-MAPK Causes Chemotherapy Resistance in Gastric Cancer Cells
Author Information
Author(s): Guo Xianling, Ma Nannan, Wang Jin, Song Jianrui, Bu Xinxin, Cheng Yue, Sun Kai, Xiong Haiyan, Jiang Guocheng, Zhang Baihe, Wu Mengchao, Wei Lixin
Primary Institution: Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, PR China
Hypothesis
The p38-MAPK signaling pathway is involved in the development of chemotherapy resistance in gastric cancer cells.
Conclusion
Inhibition of the p38-MAPK pathway can increase the sensitivity of drug-resistant gastric cancer cells to chemotherapy.
Supporting Evidence
- SGC7901/VCR cells showed increased expression of the MDR1 gene and P-glycoprotein.
- Inhibition of p38-MAPK reduced MDR1 expression and increased chemotherapy sensitivity.
- AP-1 activity was significantly higher in drug-resistant cells compared to sensitive cells.
Takeaway
Some cancer cells can become resistant to chemotherapy, but blocking a specific pathway in these cells can make them more sensitive to treatment again.
Methodology
The study used Western blot analysis, RT-PCR, and various assays to assess the role of the p38-MAPK pathway in drug-resistant gastric cancer cells.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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