Genetic Factors in Colorectal Cancer Risk
Author Information
Author(s): Abulí Anna, Fernández-Rozadilla Ceres, Alonso-Espinaco Virginia, Muñoz Jenifer, Gonzalo Victoria, Bessa Xavier, González Dolors, Clofent Joan, Cubiella Joaquin, Morillas Juan D, Rigau Joaquim, Latorre Mercedes, Fernández-Bañares Fernando, Peña Elena, Riestra Sabino, Payá Artemio, Jover Rodrigo, Xicola Rosa M, Llor Xavier, Carvajal-Carmona Luis, Villanueva Cristina M, Moreno Victor, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi
Primary Institution: Hospital Clínic, University of Barcelona
Hypothesis
A polygenic model with several common low-penetrance alleles contributes to colorectal cancer genetic predisposition.
Conclusion
ARL11, ADH1C, GALNTL2, and IL6 genetic variants may have an effect on colorectal cancer risk.
Supporting Evidence
- Four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1.
- Only rs3803185 maintained statistical significance in EPICOLON stage 2.
- The joint analysis for both stages showed significance for rs3803185.
- The study had an estimated 80% power to detect an OR as low as 1.3.
Takeaway
Scientists studied genes to see if they make people more likely to get colon cancer, but they didn't find strong evidence for most of them.
Methodology
A case-control study with two stages involving genotyping of SNPs in CRC cases and matched controls.
Limitations
The sample size may not be large enough to reach stronger conclusions for the analyzed variants.
Participant Demographics
CRC cases and matched controls from the Spanish EPICOLON consortium.
Statistical Information
P-Value
0.02
Confidence Interval
1.06-2.50
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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