STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement
Author Information
Author(s): Julian Little, Julian P.T. Higgins, John P.A. Ioannidis, David Moher, France Gagnon, Erik von Elm, Muin J. Khoury, Barbara Cohen, George Davey-Smith, Jeremy Grimshaw, Paul Scheet, Marta Gwinn, Robin E. Williamson, Guang Yong Zou, Kim Hutchings, Candice Y. Johnson, Valerie Tait, Miriam Wiens, Jean Golding, Cornelia van Duijn, John McLaughlin, Andew Paterson, George Wells, Isabel Fortier, Matthew Freedman, Maja Zecevic, Richard King, Claire Infante-Rivard, Alex Stewart, Nick Birkett
Primary Institution: University of Ottawa
Conclusion
The STREGA recommendations aim to improve the reporting quality of genetic association studies.
Supporting Evidence
- The STREGA recommendations build on the STROBE Statement to enhance reporting in genetic studies.
- Improved reporting is essential for synthesizing evidence in genetic epidemiology.
- Many genetic association studies suffer from inadequate reporting of methods and results.
Takeaway
This study provides guidelines to help scientists report their findings on how genes relate to diseases more clearly and completely.
Methodology
A multidisciplinary group developed the STREGA Statement through literature review, workshops, and electronic correspondence.
Potential Biases
Potential biases may arise from inadequate reporting and methodological problems in genetic association studies.
Limitations
The quality of reporting genetic association studies is still inadequate despite the recommendations.
Digital Object Identifier (DOI)
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