Vitamin Therapy for Severe Acute Pancreatitis
Author Information
Author(s): Bansal Dipika, Bhalla Ashish, Bhasin Deepak K., Pandhi Promila, Sharma Navneet, Rana Surinder, Malhotra Samir
Primary Institution: Postgraduate Institute of Medical Education and Research, Chandigarh, India
Hypothesis
Does antioxidant therapy improve outcomes in patients with severe acute pancreatitis?
Conclusion
Vitamin-based antioxidant therapy does not significantly benefit patients with severe acute pancreatitis.
Supporting Evidence
- No significant difference in organ dysfunction was observed between the antioxidant and control groups.
- All patients in the antioxidant group survived, while two patients in the control group died.
- The mean length of hospital stay was similar between the two groups.
Takeaway
The study tested if giving vitamins to people with a serious stomach problem helps them get better, but it didn't really make a difference.
Methodology
This was a single-center, prospective, randomized, open-label study with blinded endpoint assessment involving 39 patients with severe acute pancreatitis.
Potential Biases
The open-label nature of the study could have introduced bias.
Limitations
The study had a small sample size and was not powered to detect significant differences.
Participant Demographics
Average age was 39 years, with 75% males and 25% females.
Statistical Information
P-Value
0.034
Statistical Significance
p=1.0
Digital Object Identifier (DOI)
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