Growing Weight of OP Evidence: Parathion Linked to Metabolic Effects in Rats
2008
Parathion Linked to Metabolic Effects in Rats
publication
Evidence: moderate
Author Information
Author(s): Cynthia Washam
Primary Institution: National Institute of Environmental Health Sciences
Hypothesis
Does early-life exposure to parathion affect metabolism and contribute to obesity and diabetes?
Conclusion
The study found that early-life exposure to parathion altered metabolism in rats, potentially contributing to obesity and diabetes.
Supporting Evidence
- Parathion is linked to metabolic disorders and may contribute to obesity and diabetes.
- Male rats showed signs of prediabetes after exposure to parathion.
- Female rats exhibited disrupted glucose and lipid metabolism after exposure.
Takeaway
Rats exposed to a pesticide called parathion as babies grew up with metabolism problems, which might help explain why some people get fat or diabetic.
Methodology
Rats received daily injections of parathion during their first 4 days of life, and their metabolism was observed into adulthood.
Participant Demographics
Rats were used in the study, with observations made on both male and female subjects.
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