p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan

2005

p53 Gene Variants and Oral Cancer in Taiwan

Sample size: 629 publication 10 minutes Evidence: moderate

Author Information

Author(s): Hsieh L-L, Huang T-H, Chen I-H, Liao C-T, Wang H-M, Lai C-H, Liou S-H, Chang J T-C, Cheng A-J

Primary Institution: Chang Gung University, Tao-Yuan, Taiwan

Hypothesis

Different p53 haplotypes of exon 4–intron 3–intron 6 affect the frequency of mutations and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan.

Conclusion

The study found that the Arg allele is associated with p53 mutations, while the Pro allele is preferentially lost in OSCCs linked to smoking and areca quid chewing.

Supporting Evidence

Individuals without two Pro-W-G alleles had a higher frequency of p53 mutations.
72 out of 172 OSCCs showed loss of heterozygosity of the p53 gene.
Alcohol drinking increased the frequency of Arg allele loss in patients who smoked and chewed areca quid.

Takeaway

This study looked at how certain gene variations might affect the risk of oral cancer in men in Taiwan, finding that some gene types are linked to higher mutation rates.