Unfolded protein response in cancer: the Physician's perspective
2011
Unfolded Protein Response in Cancer
publication
Evidence: moderate
Author Information
Author(s): Li Xuemei, Zhang Kezhong, Li Zihai
Primary Institution: University of Connecticut School of Medicine
Hypothesis
The unfolded protein response (UPR) plays a critical role in cancer biology and therapy.
Conclusion
The UPR is essential for cancer cell survival and can be targeted for therapeutic interventions.
Supporting Evidence
- The UPR is activated in various tumors and is essential for tumor cell survival.
- High levels of GRP78 correlate with poor prognosis in several cancers.
- Targeting the UPR may enhance the effectiveness of cancer therapies.
Takeaway
Cancer cells can get stressed when they can't fold their proteins properly, and the UPR helps them survive this stress. If we can mess with this system, we might be able to make cancer cells die.
Methodology
This review discusses the mechanisms of UPR and its implications in cancer biology and therapeutics.
Digital Object Identifier (DOI)
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