Tissue factor, osteopontin, αvβ3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression
2000
Study on Factors Affecting Blood Vessel Growth in Brain Tumors
Sample size: 68
publication
Evidence: moderate
Author Information
Author(s): Takano S, Tsuboi K, Tomono Y, Mitsui Y, Nose T
Primary Institution: Institute of Clinical Medicine, University of Tsukuba
Hypothesis
VEGF-induced proteins play a significant role in promoting angiogenesis in gliomas.
Conclusion
The study found that tissue factor and VEGF are strong regulators of angiogenesis in human gliomas.
Supporting Evidence
- 74% of glioblastomas showed tissue factor expression in endothelial cells.
- There was a correlation between tissue factor and VEGF mRNA expression in glioma tissues.
- OPN and αvβ3 integrin were predominantly observed in glioblastomas associated with VEGF expression.
Takeaway
This study looked at how certain proteins help brain tumors grow new blood vessels, which is important for their survival.
Methodology
Immunohistochemical staining and reverse transcription polymerase chain reaction analysis were used to evaluate protein and mRNA expression.
Digital Object Identifier (DOI)
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