IMRT in Oral Cavity Cancer
Author Information
Author(s): Gabriela Studer, Roger A. Zwahlen, Klaus W. Graetz, Bernard J. Davis, Christoph Glanzmann
Primary Institution: University Hospital Zurich
Hypothesis
The aim of this work was to assess disease outcome in oral cavity cancer following IMRT.
Conclusion
Postoperative IMRT of oral cavity cancer resulted in the highest local control rate of the assessed treatment subgroups.
Supporting Evidence
- 40 of the 58 OCC patients (69%) presented with locally advanced T3/4 or recurred lesions.
- Doses between 60 and 70 Gy were applied, combined with simultaneous cisplatin based chemotherapy in 78%.
- OCC patients treated with postoperative IMRT showed the highest local control (LC) rate of all assessed treatment sequence subgroups (92% LC at 2 years).
- T1 stage resulted in an expectedly significantly higher LC rate (95%, n = 19, p < 0.05) than T2-4 and recurred stages (LC ~50–60%, n = 102).
- Analyses according to the diagnosis revealed significantly lower LC in OCC following definitive IMRT than that in pharyngeal tumors treated with definitive IMRT in the same time period (43% vs 82% at 2 years, p < 0.0001).
Takeaway
This study looked at how well a special type of radiation therapy called IMRT works for patients with mouth cancer. It found that patients who had surgery first and then IMRT had the best results.
Methodology
The study analyzed 58 consecutively irradiated oral cavity cancer patients treated with IMRT and compared their outcomes with historic cohorts treated with other methods.
Potential Biases
Different treatment intervals and follow-up periods of the historic controls may influence the outcome.
Limitations
The study has limitations including small sample sizes and retrospective design.
Participant Demographics
Approximately half the patients had floor of the mouth carcinoma, one third had tongue/floor of the mouth cancer, and 10% had tumors of the gingival/mandible.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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