Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
1999
Retinoic Acid and Meningioma Cell Behavior
publication
Author Information
Author(s): Pereda M Páez, Hopfner U, Pagotto U, Renner U, Uhl E, Arzt E, Missale C, Stalla G K
Primary Institution: Max-Planck Institute of Psychiatry
Hypothesis
Meningioma cell migration and invasion would be affected by retinoic acid.
Conclusion
Retinoic acid induces a non-invasive phenotype in meningioma cells by stimulating their adhesion to the extracellular matrix.
Supporting Evidence
- Low doses of retinoic acid inhibit in vitro invasion in meningioma cells.
- Retinoic acid does not affect cell proliferation or viability.
- Retinoic acid stimulates adhesion of meningioma cells to extracellular matrix substrates.
Takeaway
Retinoic acid helps meningioma cells stick to their surroundings and makes them less likely to invade other areas.
Methodology
The study investigated the effects of retinoic acid on meningioma cell invasion and migration in vitro.
Digital Object Identifier (DOI)
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