Jamestown Canyon Virus Seroprevalence in Connecticut
Author Information
Author(s): Jean-Denis Docquier, Francesco Luzzaro, Gianfranco Amicosante, Antonio Toniolo, Gian Maria Rossolini
Primary Institution: Universita di Siena, Italy
Hypothesis
What is the seroprevalence of Jamestown Canyon virus in Connecticut?
Conclusion
The seroprevalence surveys indicated that Jamestown Canyon virus is widespread in Connecticut, with a positivity rate of 10.1% among blood donors in 1990.
Supporting Evidence
- 164 out of 1,086 sera collected in 1990 were positive by IFA.
- 67% of IFA-positive sera were confirmed positive for JCV antibodies by PRNT.
- 57 IFA-positive specimens were found in the second serosurvey of 1,016 sera.
Takeaway
Researchers checked blood samples to see how many people had antibodies to a virus called Jamestown Canyon. They found that about 10 out of every 100 people had been exposed to it.
Methodology
Two seroprevalence surveys were conducted using indirect fluorescent assays and serum dilution plaque reduction neutralization tests.
Limitations
The IFA screening procedures are known to have poor specificity.
Participant Demographics
Blood donors in 1990 and healthy patients in 1995.
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