Soluble urokinase receptor released from human carcinoma cells: a plasma parameter for xenograft tumour studies
1999
Soluble urokinase receptor as a cancer marker
publication
Evidence: moderate
Author Information
Author(s): Holst-Hansen C, Hamers M J A G, Johannessen B E, Brünner N, Stephens R W
Primary Institution: The Finsen Laboratory, Rigshospitalet
Hypothesis
The level of soluble urokinase receptor in plasma can serve as a parameter for monitoring tumor growth in xenograft studies.
Conclusion
The levels of soluble human urokinase receptor in plasma are highly correlated with tumor volume in xenografted mice.
Supporting Evidence
- Soluble urokinase receptor is released from human breast carcinoma cells.
- The level of soluble receptor in plasma is correlated with tumor volume in mice.
Takeaway
This study found that a specific protein released from cancer cells can be measured in the blood and helps to see how big the tumors are in mice.
Methodology
The study used ELISA to measure soluble urokinase receptor levels in cultures of human breast carcinoma cells and plasma from mice with xenografted tumors.
Digital Object Identifier (DOI)
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